Frank Arfuso Selected Research

WD repeat containing planar cell polarity effector

6/2018	Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan-dextran sulfate nanoparticles enhances their expression and anti-cancer effects.
2/2016	Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.
1/2015	Secreted frizzled-related protein 4 and its implications in cancer and apoptosis.
1/2015	Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties.
10/2012	Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers.

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Frank Arfuso Research Topics

Disease

49	Neoplasms (Cancer) 11/2019 - 03/2012
13	Neoplasm Metastasis (Metastasis) 12/2019 - 02/2015
11	Inflammation (Inflammations) 01/2021 - 11/2016
11	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2014
9	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020 - 01/2014
6	Carcinogenesis 10/2018 - 11/2015
5	Chronic Disease (Chronic Diseases) 01/2020 - 02/2017
4	Breast Neoplasms (Breast Cancer) 01/2019 - 11/2017
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2016
3	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 05/2015
3	Stomach Neoplasms (Stomach Cancer) 01/2018 - 10/2015
2	Squamous Cell Carcinoma of Head and Neck 11/2019 - 01/2019
2	Insulin Resistance 10/2019 - 06/2014
2	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 10/2012
2	Mouth Neoplasms (Oral Cancer) 01/2019 - 07/2018
2	Glioma (Gliomas) 12/2018 - 01/2015
2	Glioblastoma (Glioblastoma Multiforme) 12/2018 - 01/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 01/2016
2	Hepatocellular Carcinoma (Hepatoma) 02/2017 - 12/2016
2	Hypoxia (Hypoxemia) 01/2017 - 10/2016
2	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 03/2012
1	Noncommunicable Diseases 01/2020
1	Disease Progression 01/2019
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 12/2019 - 10/2016
12	Pharmaceutical PreparationsIBA 10/2018 - 01/2014
9	Bile Acids and Salts (Bile Acids)IBA 01/2020 - 01/2015
8	Probucol (Lorelco)FDA Link 12/2019 - 01/2014
8	Transcription Factors (Transcription Factor)IBA 05/2019 - 02/2015
6	AntioxidantsIBA 11/2019 - 02/2017
6	Capsules (Microcapsules)IBA 10/2018 - 01/2014
5	Hypoglycemic Agents (Hypoglycemics)IBA 10/2018 - 01/2014
5	WD repeat containing planar cell polarity effectorIBA 06/2018 - 10/2012
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2019 - 02/2015
4	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 02/2019 - 01/2016
4	CateninsIBA 12/2018 - 12/2014
4	Gliclazide (Diamicron)IBA 10/2018 - 01/2014
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2018 - 11/2008
3	NF-kappa B (NF-kB)IBA 01/2019 - 05/2015
3	LipidsIBA 09/2018 - 06/2014
3	Biomarkers (Surrogate Marker)IBA 07/2018 - 10/2015
3	Biological ProductsIBA 01/2018 - 02/2017
3	LigandsIBA 11/2017 - 06/2015
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 01/2016
2	RNA (Ribonucleic Acid)IBA 12/2019 - 01/2017
2	ChromatinIBA 12/2019 - 01/2018
2	SurvivinIBA 11/2019 - 01/2019
2	buteinIBA 11/2019 - 02/2017
2	Neuroprotective AgentsIBA 05/2019 - 02/2017
2	formononetinIBA 05/2019 - 01/2018
2	Therapeutic UsesIBA 05/2019 - 10/2018
2	EnzymesIBA 03/2019 - 01/2018
2	Cadherins (E-Cadherin)IBA 01/2019 - 12/2016
2	Histones (Histone)IBA 01/2019 - 01/2018
2	Secreted Frizzled-Related ProteinsIBA 01/2019 - 01/2014
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2018
2	Cisplatin (Platino)FDA LinkGeneric 07/2018 - 10/2012
2	Glycoproteins (Glycoprotein)IBA 07/2018 - 04/2016
2	3-methylquercetinIBA 01/2018 - 10/2015
2	thymoquinoneIBA 01/2018 - 01/2017
2	CytokinesIBA 01/2018 - 02/2015
2	IsoflavonesIBA 01/2018 - 03/2012
2	Indicators and Reagents (Reagents)IBA 01/2018 - 01/2018
2	ResveratrolIBA 12/2017 - 01/2017
2	PolyphenolsIBA 12/2017 - 02/2017
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 11/2017 - 01/2017
2	Phosphotransferases (Kinase)IBA 11/2017 - 11/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2017 - 01/2017
2	CurcuminIBA 01/2017 - 02/2015
2	Glucose (Dextrose)FDA LinkGeneric 11/2016 - 06/2014
2	Insulin (Novolin)FDA Link 11/2016 - 06/2014
2	phenoxodiolIBA 01/2014 - 03/2012
1	Lipoproteins (Lipoprotein)IBA 01/2021
1	Amyloid beta-PeptidesIBA 01/2021
1	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA 01/2020
1	PolymersIBA 12/2019
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 10/2019
1	Antineoplastic Agents (Antineoplastics)IBA 05/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 03/2019
1	Histone Deacetylase InhibitorsIBA 03/2019
1	zerumboneIBA 02/2019
1	Janus Kinase 2IBA 02/2019
1	Interleukin-6 (Interleukin 6)IBA 02/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Olive OilIBA 01/2019
1	oxymatrineIBA 01/2019
1	Biocompatible Materials (Biomaterials)IBA 01/2019
1	Estrogen ReceptorsIBA 01/2019
1	Cyclin D1IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Benzo(a)pyreneIBA 01/2019
1	oleuropeinIBA 01/2019
1	Nicotine FDA Link 01/2019
1	AlginatesIBA 01/2019
1	thiazolyl blueIBA 01/2019

Therapy/Procedure

26	Therapeutics 05/2019 - 10/2012
5	Drug Therapy (Chemotherapy) 05/2019 - 10/2012
2	Radiotherapy 12/2016 - 10/2016
1	Long-Term Care 01/2020
1	Traditional Medicine (Folk Remedies) 01/2019